Your desk may have a lot of drawers, but some of your more important accessories - flash drives, USB cables, and the like - probably get lost in all the chaos. If that sounds like you, consider getting a 5.25" drawer like this one from Case Box that fits right into your front drive bay. It may not be as flashy as some of the other items on this list, but it's practical as heck, and almost certainly better than leaving the bay unused. You could even rip out the plastic sleeves from a cheap CD case and keep all your installation discs and other CDs in there, if you can't think of what to do with it.